A Randomized Clinical Trial of Dexmedetomidine on Delirium, Cognitive Dysfunction, and Sleep After Non-Ambulatory Orthopedic Surgery With Regional Anesthesia
Sedation with dexmedetomidine resulted in a statistically and clinically important reduction in the incidence of POD, ED, and early POCD, while it improved self-reported postoperative sleep quality and reduced chronic pain scores in patients undergoing major elective lower limb surgery under regional anesthesia.
Authors
- Maria Christofaki
- Anastasia Spartinou (ORCID: https://orcid.org/0000-0001-7732-7691)
- Panagiota Darivianaki
- A. Chatzimichali
- Αλεξάνδρα Παπαϊωάννου (ORCID: https://orcid.org/0000-0002-5710-4279)
- Vasileia Nyktari (ORCID: https://orcid.org/0000-0002-5863-3236)
- Vlasios Karageorgos
- Panagiotis G. Simos (ORCID: https://orcid.org/0000-0002-0116-8564)
Institutions
- University of Crete (GR)
- University Hospital of Heraklion (GR)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1213/ane.0000000000007548
- Citations
- 9
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 13.91