Neoadjuvant PD-1 and PD-L1 Blockade With Chemotherapy for Borderline Resectable and Unresectable Stage III Non–Small Cell Lung Cancer
In this study, neoadjuvant PD-1/PD-L1 blockade combined with chemotherapy resulted in high pathological response rates and surgical resectability in patients with T4 and/or N2-N3 stage III NSCLC. This approach offers a viable treatment option for patients with borderline resectable or unresectable NSCLC but requires further validation through prospective studies.
Authors
- Federico Cappuzzo (ORCID: https://orcid.org/0000-0002-6295-6767)
- Gabriele Minuti (ORCID: https://orcid.org/0000-0003-2363-0446)
- Filippo Tommaso Gallina (ORCID: https://orcid.org/0000-0001-5579-0837)
- Xinan Wang (ORCID: https://orcid.org/0000-0001-5236-1105)
- Simonetta Buglioni (ORCID: https://orcid.org/0000-0002-5066-1523)
- Federica Pecci (ORCID: https://orcid.org/0009-0000-9289-2007)
- Edoardo Garbo (ORCID: https://orcid.org/0000-0003-2394-9895)
- Michelle S. Ginsberg (ORCID: https://orcid.org/0000-0003-0304-110X)
- Paula A. Ugalde (ORCID: https://orcid.org/0000-0003-4284-444X)
- Rocco Trisolini (ORCID: https://orcid.org/0000-0002-1067-4696)
- Narek Shaverdian (ORCID: https://orcid.org/0000-0002-0294-8749)
- Erino Angelo Rendina (ORCID: https://orcid.org/0000-0003-1839-7512)
- Enrico Melis (ORCID: https://orcid.org/0009-0002-8076-7553)
- Biagio Ricciuti (ORCID: https://orcid.org/0000-0002-0651-2678)
- Matthew Joseph Bott (ORCID: https://orcid.org/0000-0003-0523-4028)
- Sara Ramella (ORCID: https://orcid.org/0000-0002-5782-7717)
- Valentina Santo (ORCID: https://orcid.org/0009-0006-7587-9445)
- Alissa J. Cooper (ORCID: https://orcid.org/0000-0001-9124-0082)
- Francesca Fusco (ORCID: https://orcid.org/0000-0002-9768-5768)
- Mihaela D. Aldea (ORCID: https://orcid.org/0000-0001-7685-051X)
- Lorenza Maria Landi (ORCID: https://orcid.org/0000-0003-2604-6595)
- Mizuki Nishino (ORCID: https://orcid.org/0000-0003-0275-0502)
- Alessandro Di Federico (ORCID: https://orcid.org/0000-0001-8877-4315)
- Alice Tsang Shaw (ORCID: https://orcid.org/0000-0001-6337-1093)
- Mark M. Awad (ORCID: https://orcid.org/0000-0003-0928-5244)
- Jamie E. Chaft (ORCID: https://orcid.org/0000-0002-5838-9982)
- Lynette M. Sholl (ORCID: https://orcid.org/0000-0002-9532-9735)
- Mireia Peñalva
Institutions
- Brigham and Women's Hospital (US)
- Memorial Sloan Kettering Cancer Center (US)
- Harvard University (US)
- Università Campus Bio-Medico (IT)
- Agostino Gemelli University Polyclinic (IT)
- Dana-Farber Cancer Institute (US)
- Azienda Ospedaliera Sant'Andrea (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1001/jamaoncol.2025.1115
- Citations
- 16
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 24.29