Mutagenic Impact and Evolutionary Influence of Chemoradiotherapy in Hematologic Malignancies
RT and the ID8 indel signature are related, but their genomic impact on hematologic malignancies is unclear. Leveraging WGS, we linked ID8 to both RT and mutagenic chemotherapy and validated that platinum can induce ID8. We used ID8 as a genomic barcode to reveal that RT-resistant cells may seed systemic relapse.
Authors
- Benjamin T. Diamond (ORCID: https://orcid.org/0000-0002-8638-9365)
- Michael David Jain (ORCID: https://orcid.org/0000-0002-7789-1257)
- Kylee H. Maclachlan (ORCID: https://orcid.org/0000-0001-7873-4854)
- Saad Z. Usmani (ORCID: https://orcid.org/0000-0002-5484-8731)
- Frederick Lundry Locke (ORCID: https://orcid.org/0000-0001-9063-6691)
- Katja Christina Weisel (ORCID: https://orcid.org/0000-0001-9422-6614)
- Nicholas Figura (ORCID: https://orcid.org/0000-0002-6885-3320)
- Alexandra M. Poos
- Faith E. Davies (ORCID: https://orcid.org/0000-0002-3971-2393)
- Dhanvantri Chahar (ORCID: https://orcid.org/0000-0002-7623-7018)
- Bachisio Ziccheddu (ORCID: https://orcid.org/0000-0002-2746-0053)
- Niels Weinhold (ORCID: https://orcid.org/0000-0002-5464-3234)
- Hartmut Goldschmidt (ORCID: https://orcid.org/0000-0003-0961-0035)
- Marios Papadimitriou (ORCID: https://orcid.org/0009-0009-1852-3495)
- Jonathan Harry Schatz (ORCID: https://orcid.org/0000-0003-1842-228X)
- Marcella Kaddoura (ORCID: https://orcid.org/0000-0002-4529-7405)
- Marc S. Raab (ORCID: https://orcid.org/0000-0003-4181-6922)
- Michael Durante (ORCID: https://orcid.org/0000-0003-3137-6847)
- K. Elias (ORCID: https://orcid.org/0000-0002-6226-1252)
- Tomáš Jelı́nek (ORCID: https://orcid.org/0000-0002-5467-9253)
- Ola Landgren (ORCID: https://orcid.org/0000-0001-6485-4839)
- Roland Fenk (ORCID: https://orcid.org/0000-0001-7594-6288)
- Francesco Maura (ORCID: https://orcid.org/0000-0002-5017-1620)
- Gareth J. Morgan (ORCID: https://orcid.org/0000-0002-4271-6360)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- University of Miami (US)
- Universität Hamburg (DE)
- German Cancer Research Center (DE)
- University of Ostrava (CZ)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Moffitt Cancer Center (US)
- NYU Langone Health (US)
- University Hospital Ostrava (CZ)
- Düsseldorf University Hospital (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Sylvester Comprehensive Cancer Center (US)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1158/2643-3230.bcd-24-0328
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00