Distinct Transcriptomic Profiles of Cultured Anterior and Posterior Populations of Human Infant Scleral Fibroblasts: Including Dopamine Receptors
To our knowledge, this study presents the first comprehensive transcriptomic profiling of infant scleral fibroblasts, revealing their heterogeneity. The investigation of the regulatory role of DA receptor activity and expression in DA-mediated inhibition of scleral fibroblast contraction provides new insights into how DA signaling modulates scleral remodeling.
Authors
- Yingfeng Zheng (ORCID: https://orcid.org/0000-0002-0914-7864)
- Jiali Guan
- Guangliang Hong (ORCID: https://orcid.org/0000-0002-5822-7705)
- Dajiang Qin (ORCID: https://orcid.org/0009-0008-2792-3514)
- Jiangping He (ORCID: https://orcid.org/0000-0002-1425-3530)
- He Li (ORCID: https://orcid.org/0000-0001-6429-9097)
- Zhong Liu (ORCID: https://orcid.org/0000-0003-3067-1967)
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Guangzhou Institutes of Biomedicine and Health (CN)
- Guangzhou Regenerative Medicine and Health Guangdong Laboratory (CN)
- State Key Laboratory of Respiratory Disease (CN)
- University of Chinese Academy of Sciences (CN)
- University of Hong Kong (HK)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1167/iovs.66.5.29
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00