Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure
Plasma sST2 levels independently predict outcomes in ARF and are strongly associated with extrapulmonary organ dysfunction. The weak correlation between plasma and LRT sST2 levels suggests a predominantly systemic source. These findings highlight the potential of the IL-33/ST2 axis as a therapeutic target and warrant further investigation into its role in multiple organ dysfunction in ARF.
Authors
- Xiahong Wang
- Faraaz Shah (ORCID: https://orcid.org/0000-0002-2847-7738)
- John Evankovich (ORCID: https://orcid.org/0000-0003-2070-0883)
- Raj Ramanan (ORCID: https://orcid.org/0000-0002-1970-2964)
- Charles S. Dela Cruz (ORCID: https://orcid.org/0000-0002-5258-1797)
- Francesca Giacona
- Anuradha Ray (ORCID: https://orcid.org/0000-0001-6844-8918)
- Panayiotis V. Benos (ORCID: https://orcid.org/0000-0003-3172-3132)
- William Bain (ORCID: https://orcid.org/0000-0001-8506-0552)
- Holt Murray (ORCID: https://orcid.org/0000-0002-5610-2474)
- Elizabeth Abe (ORCID: https://orcid.org/0009-0006-6283-0562)
- Benjamin E. Zuchelkowski (ORCID: https://orcid.org/0000-0002-0747-292X)
- Amy S. Labar
- Bryan C. Ulrich (ORCID: https://orcid.org/0000-0003-1225-9784)
- Mehdi syed Nouraie (ORCID: https://orcid.org/0000-0001-7465-0581)
- Ghady Haidar (ORCID: https://orcid.org/0000-0003-0634-8211)
- Georgios D. Kitsios (ORCID: https://orcid.org/0000-0002-1018-948X)
- Shulin Qin (ORCID: https://orcid.org/0000-0003-2496-3007)
- Prabir Ray (ORCID: https://orcid.org/0000-0002-0430-5114)
- Tyler Lovelace (ORCID: https://orcid.org/0000-0002-7881-9054)
- Bryan J. McVerry (ORCID: https://orcid.org/0000-0002-1175-4874)
- Mark E. Snyder (ORCID: https://orcid.org/0000-0002-0092-9296)
- Barbara A. Methé (ORCID: https://orcid.org/0000-0001-8711-1448)
- Eric P. Schmidt (ORCID: https://orcid.org/0000-0002-7360-0504)
- Haopu Yang (ORCID: https://orcid.org/0000-0001-6858-1778)
- Jehan Alladina (ORCID: https://orcid.org/0000-0003-0136-6859)
- Heth Roderick Turnquist (ORCID: https://orcid.org/0000-0002-4173-4014)
- George A. Alba (ORCID: https://orcid.org/0000-0002-6876-7836)
- Yingze Zhang
- B. Taylor Thompson (ORCID: https://orcid.org/0000-0001-6391-0448)
- Alison Morris (ORCID: https://orcid.org/0000-0002-7290-6536)
- Emma B. White
Institutions
- University of Pittsburgh (US)
- University of Florida (US)
- Massachusetts General Hospital (US)
- VA Pittsburgh Healthcare System (US)
- University of Pittsburgh Medical Center (US)
- Tsinghua University (CN)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1097/ccm.0000000000006716
- Citations
- 7
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 5.58