Osteopontin protects from ovalbumin-induced asthma by preserving the microbiome and the intestinal barrier function
Osteopontin deficiency exacerbated asthmatic airway inflammation, an effect associated with microbiota dysbiosis, impaired intestinal barrier function, and increased PD-1/PD-L1 expression and thus decreased Treg cell function. The study provides clinicians with new insights into asthma mechanisms and can also lead to new ideas for asthma treatment.
Authors
- Hongyu Qiao
- Hui Su (ORCID: https://orcid.org/0009-0007-4406-2333)
- Qiuhong Li (ORCID: https://orcid.org/0000-0002-2950-0928)
- Jinli Huang
- Xin Sun (ORCID: https://orcid.org/0000-0002-5573-551X)
- Chen‐Yu Zhang (ORCID: https://orcid.org/0000-0002-7329-7162)
- Yi Zhang (ORCID: https://orcid.org/0000-0001-6223-4724)
Institutions
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- mSystems
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1128/msystems.00389-25
- Citations
- 3
- Primary Topic
- Digestive system and related health
- Type
- article
- Field-Weighted Citation Impact
- 5.45