Nalidixic acid—a good marker of fluoroquinolone resistance mechanisms in <i>Escherichia coli</i>
We show in our clinical setting that fluoroquinolone resistance mechanisms are discovered, even among phenotypically fluoroquinolone-susceptible <i>Escherichia coli</i> isolates. When plasmid-mediated quinolone-resistance determinants are present, they are a potential risk for treatment failures due to accumulation of resistance mechanisms during the antimicrobial treatment. Therefore, when it is clinically relevant, fluoroquinolone resistance mechanisms in <i>E. coli</i> should be monitored more closely, and we also recommend testing nalidixic acid susceptibility.
Authors
- Sofia Kalinen (ORCID: https://orcid.org/0000-0002-3893-0866)
- Antti Hakanen (ORCID: https://orcid.org/0000-0003-4180-0306)
- Heini Kallio
- Tarja Lamminen (ORCID: https://orcid.org/0000-0002-9556-687X)
- Teemu Kallonen (ORCID: https://orcid.org/0000-0003-1741-6486)
- Marianne Gunell (ORCID: https://orcid.org/0000-0002-4347-3233)
- Juha Knaapila (ORCID: https://orcid.org/0000-0003-0997-9668)
- Pentti Huovinen (ORCID: https://orcid.org/0000-0003-0003-1539)
- Peter J. Boström (ORCID: https://orcid.org/0000-0003-3647-0015)
Institutions
- University of Turku (FI)
- Turku University Hospital (FI)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1128/spectrum.01974-24
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- Sigrid Juséliuksen Säätiö
- Syöpäsäätiö