Highly regio-selective hydration of ynamides under catalyst-free conditions
The highly regio-selective hydration of ynamides under catalyst-free conditions has been demonstrated for easily accessing α-amidoketones in 51-99% yields. The excellent regio-selectivity is believed to be controlled by the amide group, which is just opposite to that observed in Brønsted acid-mediated hydration of ynamides. This approach is highly convenient, easy to operate, and exhibits good functionality tolerance.
Authors
- Peng Bao (ORCID: https://orcid.org/0000-0002-8070-0589)
- Yeqing Wang (ORCID: https://orcid.org/0000-0002-5673-9897)
- Qiuwen Li
- Han Xiao (ORCID: https://orcid.org/0000-0001-5655-0173)
- Gang He (ORCID: https://orcid.org/0000-0002-9064-3418)
- Yi Wang (ORCID: https://orcid.org/0000-0001-6154-945X)
Institutions
- Nanjing Tech University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00581g
- Citations
- 1
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China