Relationship of dysbiosis with autism spectrum Disorder

Introduction: Autism Spectrum Disorder (ASD) encompasses neurological development disorders present from birth. According to the Diagnostic and Statistical Manual of Mental Disorders DSM-5, this neuropsychiatric condition manifests itself in two main areas, persistent deficits in social communication and interaction in multiple contexts (verbal or non-verbal languages and socio- emotional reciprocity) as well as restrictive patterns and repetitive behavior, interests or activities. A recent line of research on autism has focused on the microbiota-gut-brain axis. Alteration of the gut microbiota or Dysbiosis has been implicated in neurodevelopmental behavioral changes and gastrointestinal problems in patients with autism spectrum disorder (ASD).Materials and methods: To carry out this review, a bibliographic search of scientific articles in computerized databases such as Pubmed and Scielo was used.Conclusion: Various studies have found that children with ASD present significant differences in the intestinal microbiota compared to neurotypical children. These differences not only seem to influence gastrointestinal symptoms, common in people with ASD, but also behavioral ones.