Stimulation of Soluble Guanylyl Cyclase (sGC) by Cinaciguat Attenuates Sepsisinduced Cardiac Injury
We demonstrated that cinaciguat alleviated LPS-induced cardiac dysfunction, inflammation, and apoptosis through the PRKG1/CREB/FtMt pathway, thereby protecting against LPS-induced cardiac injury. This study identified a new strategy for treating cardiac injury caused by sepsis.
Authors
- Guang Chen (ORCID: https://orcid.org/0000-0001-7551-2957)
- Ronghai Lin
- Cheng Zheng (ORCID: https://orcid.org/0000-0002-6562-870X)
- Enjian Shen (ORCID: https://orcid.org/0000-0002-9836-7972)
- Wanqian Li (ORCID: https://orcid.org/0000-0003-3741-535X)
- Xijiang Zhang (ORCID: https://orcid.org/0000-0002-1742-960X)
- Lingjun Wang (ORCID: https://orcid.org/0000-0002-1431-3214)
- Binhui Wang (ORCID: https://orcid.org/0000-0002-7803-1785)
Institutions
- Taizhou Municipal Hospital (CN)
- Taizhou Central Hospital (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Current Molecular Pharmacology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.2174/0118761429387280250506114040
- Citations
- 5
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- Health Commission of Zhejiang Province
- Natural Science Foundation of Zhejiang Province