GDNF enhances HGF-induced tubulogenesis and organization of Sertoli cell
Our study reveals that exogenous GDNF enhances the HGF-induced tubular organization of Sertoli cells in vitro. The concurrent administration of GDNF and HGF markedly augments the formation of tubular structures and the expression of the ZO-1 protein, indicating a potential synergistic influence on the organizational and signaling cascades within Sertoli cells.
Authors
- Çiler Çelik-Özenci (ORCID: https://orcid.org/0000-0003-0370-8680)
- Begüm Durkut (ORCID: https://orcid.org/0000-0002-4271-5763)
Institutions
- Koç University (TR)
Publication Details
- Journal
- Journal of Assisted Reproduction and Genetics
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1007/s10815-025-03493-7
- Citations
- 1
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi
- Koç Üniversitesi