First dose target attainment with extended infusion regimens of piperacillin and meropenem
Despite aggressive dosing, plasma concentrations often fail to reach 100% fT > MIC during the first dosing interval. Alternative regimens and early plasma concentration measurements followed by adaptive dose adjustments should be considered to improve target attainment.
Authors
- O. Breuer
- Christian G. Giske (ORCID: https://orcid.org/0000-0003-4327-6122)
- Erik Eliasson (ORCID: https://orcid.org/0000-0002-4707-4256)
- Johan Petersson (ORCID: https://orcid.org/0000-0003-1838-2775)
- Maria Swartling (ORCID: https://orcid.org/0000-0001-8816-0567)
- Elisabet I. Nielsen (ORCID: https://orcid.org/0000-0003-0725-214X)
- Gustaf Beijer
Institutions
- Uppsala University (SE)
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Critical Care
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s13054-025-05445-0
- Citations
- 7
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 9.76
Funders
- VINNOVA
- Karolinska Institutet