DEVELOPMENT OF SR METFORMIN HCL TABLET USING FLAX AND CHIA SEED MUCILAGE

Aim: This work is to Development of SR Metformin HCl tablet using flax and chia seed mucilage. Methods: This present study was to design of SR Metformin HCl tablets using flax and chia seed mucilage. The mucilage was extracted from flax and chia seeds via hot extraction method. Metformin HCl tablets were prepared using mucilage by wet granulation method and then optimized SR action by in vitro studies. Results: The formulated tablets were evaluated for physical characteristics like weights variations, hardness, friability, drug content and drug release that fulfilled all the official requirements of tablet dosage form. The release rate of SR tablets were carried out in HCl (pH1.2) followed by phosphate buffer (pH 6.8). In-vitro release study shows that the mucilage based SR formulations (TS9) exhibited the highest correlation value (r2) for Higuchi kinetic model. Conclusion: In vitro studies indicated that the formulation showed better sustained release action.