Sex differences in the modulation of anxiety- and depression-like behaviors by matrix metalloproteinase-9 expression levels in mice
MMP-9 activity modifies anxiety- and depression-like behaviors, as well as neuroplasticity markers, in female but not in male mice. These findings reinforce the sex differences in the etiopathology of depression.
Authors
- Athina Tzinia
- Albert Adell (ORCID: https://orcid.org/0000-0003-0570-4931)
- Eva Florensa-Zanuy (ORCID: https://orcid.org/0000-0001-5045-7680)
- Ángel Pazos (ORCID: https://orcid.org/0000-0001-8047-8802)
- Álvaro Díaz (ORCID: https://orcid.org/0000-0002-8783-4555)
- Júlia Senserrich (ORCID: https://orcid.org/0000-0001-6518-2456)
- Fuencisla Pilar-Cuéllar (ORCID: https://orcid.org/0000-0003-1229-001X)
- Elena Castro (ORCID: https://orcid.org/0000-0002-6750-5519)
Institutions
- Universidad de Cantabria (ES)
- National Centre of Scientific Research "Demokritos" (GR)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Instituto de Biomedicina y Biotecnología de Cantabria (ES)
- Institute of Biosciences & Applications
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s13293-025-00716-5
- Citations
- 1
- Primary Topic
- Neuropeptides and Animal Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Centro de Investigación Biomédica en Red de Salud Mental
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación