METTL3-Mediated m <sup>6</sup> A mRNA Modification Facilitates Neointimal Hyperplasia in Arteriovenous Fistula
The METTL3-YTHDF1-SLC7A11 axis facilitates AVF NIH by regulating vascular smooth muscle cell dedifferentiation and ferroptosis. These findings uncover a novel epitranscriptional mechanism and suggest a potential therapeutic target for AVF stenosis.
Authors
- Zhenwei Pan (ORCID: https://orcid.org/0000-0002-1011-0954)
- J. B. Jiao (ORCID: https://orcid.org/0000-0003-0049-1359)
- Chengwei Zhang (ORCID: https://orcid.org/0000-0002-2110-5501)
- Benzhi Cai (ORCID: https://orcid.org/0000-0003-0017-867X)
- Zhaozheng Li (ORCID: https://orcid.org/0000-0003-4848-0798)
- Yao Zhao (ORCID: https://orcid.org/0000-0002-8333-6348)
- Huimin Ma (ORCID: https://orcid.org/0000-0001-7440-2027)
Institutions
- Harbin Medical University (CN)
- Heilongjiang University of Chinese Medicine (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Heilongjiang University (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1161/atvbaha.124.321014
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.22