Role of biliverdin reductase, a heme degradation pathway enzyme, in the development of vasospasm after subarachnoid hemorrhage
This study shows a novel role of BV in vasospasm development and identifies oxidative modifications of BVR-A as potential modulators of SAH pathology. These findings suggest that BV and altered BVR-A activity may serve as biomarkers or therapeutic targets for improving outcomes in patients with SAH.
Authors
- Shawna Amini (ORCID: https://orcid.org/0000-0002-6241-3770)
- Koji Hosaka (ORCID: https://orcid.org/0000-0003-0106-4586)
- Brandon Peter Lucke-Wold (ORCID: https://orcid.org/0000-0001-6577-4080)
- Melanie Martinez (ORCID: https://orcid.org/0000-0001-8171-8839)
- Elizabeth Klaas (ORCID: https://orcid.org/0000-0001-6845-2052)
- Brian Lim Hoh (ORCID: https://orcid.org/0000-0002-4997-4469)
- Zahra Hasanpour Segherlou (ORCID: https://orcid.org/0000-0003-2001-0268)
- Haiyan Xu (ORCID: https://orcid.org/0009-0009-6014-2792)
- Hunter J. Hutchinson (ORCID: https://orcid.org/0009-0005-3202-3949)
Institutions
- University of Florida Health (US)
- University of Florida (US)
- Florida College (US)
Publication Details
- Journal
- Journal of NeuroInterventional Surgery
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1136/jnis-2025-023108
- Primary Topic
- Intracranial Aneurysms: Treatment and Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00