Single-Cell and Spatial Transcriptomics Identified Fatty Acid–Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension
PH causes aberrant expression of FABP4/5 in pulmonary ECs, which leads to enhanced EC glycolysis and distal arterial programming, contributing to the accumulation of arterial ECs and vascular remodeling and exacerbating the disease.
Authors
- Hanqiu Zhao
- Vladimir V. Kalinichenko (ORCID: https://orcid.org/0000-0003-3438-2660)
- Zhiyu Dai (ORCID: https://orcid.org/0000-0002-2945-7923)
- Ruslan Rafikov (ORCID: https://orcid.org/0000-0001-5950-4076)
- Xiaomei Xia (ORCID: https://orcid.org/0009-0002-9679-4556)
- Haiwei Gu (ORCID: https://orcid.org/0000-0002-7598-5022)
- Shenfeng Qiu (ORCID: https://orcid.org/0000-0002-0730-1602)
- Kenneth S. Knox (ORCID: https://orcid.org/0000-0002-5261-6558)
- Sébastien Bonnet (ORCID: https://orcid.org/0000-0001-5753-1900)
- Christopher C. Glembotski (ORCID: https://orcid.org/0000-0002-1380-5073)
- Sarah‐Eve Lemay (ORCID: https://orcid.org/0000-0002-6625-9918)
- Mrinalini Kala (ORCID: https://orcid.org/0000-0002-2527-9787)
- Michael B. Fallon (ORCID: https://orcid.org/0000-0003-4087-803X)
- You‐Yang Zhao (ORCID: https://orcid.org/0000-0002-0041-0339)
- Shuai Li (ORCID: https://orcid.org/0000-0003-4898-6473)
- Ankit Tripathi (ORCID: https://orcid.org/0009-0000-5019-2379)
- Vinicio de Jesús Pérez (ORCID: https://orcid.org/0000-0001-5532-8247)
- Olivier Boucherat (ORCID: https://orcid.org/0000-0002-5251-7488)
- Bin Liu (ORCID: https://orcid.org/0000-0003-1569-2604)
- Dan Yi (ORCID: https://orcid.org/0000-0002-2614-5027)
- Yanhong Cao (ORCID: https://orcid.org/0000-0001-5790-6258)
- Karina Ramirez (ORCID: https://orcid.org/0000-0001-5982-2138)
Institutions
- Northwestern University (US)
- University of Arizona (US)
- Palo Alto University (US)
- University of Phoenix (US)
- Washington University in St. Louis (US)
- Phoenix Children's Hospital (US)
- Lurie Children's Hospital (US)
- Ping (United States) (US)
- Université Laval (CA)
- Arizona State University (US)
- Indiana University – Purdue University Indianapolis (US)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1161/atvbaha.124.321173
- Citations
- 9
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 13.67