PARylation of POLG Mediated by PARP1 Accelerates Ferroptosis-Induced Vascular Calcification via Activating Adora2a/Rap1 Signaling
Our study establishes the critical role of PARP1-mediated PARylation-dependent ubiquitination of POLG in VSMC ferroptosis-induced VC. These findings suggest that PARP1 inhibitors could potentially serve as novel therapeutic strategies for VC.
Authors
- Naifeng Liu (ORCID: https://orcid.org/0000-0001-9998-1889)
- Wei Qin (ORCID: https://orcid.org/0000-0001-8042-8784)
- Shengjue Xiao (ORCID: https://orcid.org/0000-0003-2561-3260)
- Yuyu Yao (ORCID: https://orcid.org/0000-0001-7841-288X)
- Liqun Ren (ORCID: https://orcid.org/0000-0002-1132-8613)
- Yiqing Yang (ORCID: https://orcid.org/0000-0001-6090-1378)
- Xiaoxue Li (ORCID: https://orcid.org/0000-0003-3581-3442)
Institutions
- Zhongda Hospital Southeast University (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1161/atvbaha.124.321682
- Citations
- 9
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 13.67