Influence of co-pathology on CSF and plasma synaptic markers SNAP25 and VAMP2 in Alzheimer’s disease and Parkinson’s disease
SNAP25 reliably serves as a marker of synaptic injury when measured in both CSF and plasma, whereas VAMP2 demonstrates reliability exclusively in CSF. Both markers are primarily influenced by AD pathology and remain unaffected by α-synucleinopathy, suggesting their potential in detecting AD-related synaptic dysfunction.
Authors
- Lucilla Parnetti (ORCID: https://orcid.org/0000-0001-5722-3967)
- Julie Goossens (ORCID: https://orcid.org/0000-0001-5336-1238)
- Davide Chiasserini (ORCID: https://orcid.org/0000-0002-1169-3258)
- Federico Paolini Paoletti (ORCID: https://orcid.org/0000-0001-9623-1900)
- Giovanni Bellomo (ORCID: https://orcid.org/0000-0003-0456-5650)
- Eugeen Vanmechelen (ORCID: https://orcid.org/0000-0002-9466-5366)
- Lorenzo Gaetani (ORCID: https://orcid.org/0000-0003-3967-8954)
- Charlotte De Rocker
Institutions
- Ablynx (Belgium) (BE)
- University of Perugia (IT)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s13195-025-01762-2
- Citations
- 6
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- Parkinson's Foundation
- Associazione Italiana Ricerca Alzheimer