HBV sequence integrated to enhancer acting as oncogenic driver epigenetically promotes hepatocellular carcinoma development
HBV-SITEs were identified as novel oncogenic elements for HCC, which provides an insightful perspective for the other cancers caused by oncogenic DNA viruses. We demonstrated that the integrated HBV sequence itself acted as oncogenic enhancers and nucleotide variations of HBV genotypes account for particular pathogenic progression, supporting that the viral nucleotide sequences are vital pathogenic substances beyond viral proteins. And modulation of their enhancer activities could be clinically achievable strategy for blocking DNA viruses-related cancer progression in the future.
Authors
- Xian‐Long Meng
- Wenqiang Yu (ORCID: https://orcid.org/0000-0001-9920-1133)
- Kaicheng Zhou (ORCID: https://orcid.org/0009-0008-4731-1005)
- Qunyan Yao (ORCID: https://orcid.org/0000-0003-3586-1911)
- Xiangyi Zheng (ORCID: https://orcid.org/0009-0000-3051-8896)
- Mu Ye
- Ying Liang
- Zhanrui Mao (ORCID: https://orcid.org/0000-0001-6809-4742)
- Zhenghong Yuan (ORCID: https://orcid.org/0000-0003-0268-4891)
- Wenjing Zai (ORCID: https://orcid.org/0000-0002-4870-1143)
- Wei Li (ORCID: https://orcid.org/0000-0002-4264-1864)
- Lu Chen (ORCID: https://orcid.org/0000-0002-3797-3872)
- Hongyan Wei (ORCID: https://orcid.org/0000-0002-0656-8639)
- Wenxuan Li (ORCID: https://orcid.org/0000-0002-4759-6038)
- Zhicong Yang (ORCID: https://orcid.org/0000-0001-5409-4290)
- Mengxing Liu
- Guo‐Ming Shi (ORCID: https://orcid.org/0000-0003-3446-7875)
- Shuai Yang (ORCID: https://orcid.org/0000-0002-5096-4356)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- Huashan Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1186/s13046-025-03413-8
- Citations
- 3
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- National Natural Science Foundation of China