Mechanism of Protective Effect of Mongolia Medicine Nagab-9 on LPS-Induced Acute Lung Injury Based on an Integrated Network Pharmacology and Experimental Verification
Nagab-9 exerts a protective effect against ALI by modulating inflammatory responses and reducing neutrophil infiltration and NET formation, primarily via the SRC/ERK1/2/STAT3 signaling pathway. This study supports Nagab-9 as a promising therapeutic agent for ALI intervention.
Authors
- Jiuwang Yu (ORCID: https://orcid.org/0009-0003-2214-8719)
- Shi Liu (ORCID: https://orcid.org/0000-0002-4916-9312)
- Lidao Bao
- Zeyu Chen (ORCID: https://orcid.org/0000-0001-6393-1986)
Institutions
- Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Dose-Response
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1177/15593258251329989
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Inner Mongolia