Integrating brain imaging features and genomic profiles for the subtyping of major depression
Our approach successfully stratified MDD patients into subgroups with distinct clinical prognoses. The identification of biologically and clinically meaningful subtypes may enable more personalized treatment strategies. This study also provides a framework for disease subtyping that can be extended to other complex disorders.
Authors
- Hon‐Cheong So (ORCID: https://orcid.org/0000-0002-7102-833X)
- Liangying Yin (ORCID: https://orcid.org/0000-0002-1029-7317)
- Simon S. Y. Lui (ORCID: https://orcid.org/0000-0001-9360-6244)
- Yuping Lin (ORCID: https://orcid.org/0000-0002-9546-3889)
- Jinghong Qiu
- Ming Li (ORCID: https://orcid.org/0000-0001-9553-4811)
- Xiao Xiao (ORCID: https://orcid.org/0000-0003-3608-6208)
- Yong Xiang
Institutions
- Chinese University of Hong Kong (HK)
- Kunming Institute of Zoology (CN)
- Chinese Academy of Sciences (CN)
- Castle Peak Hospital (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- University of Chinese Academy of Sciences (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/s0033291725001096
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Chinese University of Hong Kong
- Innovation and Technology Fund