MOTS-c-modified functional self-assembly peptide hydrogels enhance the activity of nucleus pulposus-derived mesenchymal stem cells of intervertebral disc degeneration
This work (1) demonstrates the association between MOTS-c's anti-degenerative effects and AMPK/SIRT1 signaling in NP-MSCs and (2) pioneers a peptide-hydrogel hybrid system that synergistically combines mitochondrial protection with structural support for disc regeneration. The findings can advance IDD therapy toward biology-driven, minimally invasive solutions, aligning with the paradigm of functional biomaterials for degenerative diseases.
Authors
- Shanzhong Shao
- Zhiwei Huang (ORCID: https://orcid.org/0000-0002-0352-7364)
- Tianyong Wen (ORCID: https://orcid.org/0000-0002-6193-8313)
- Xing Shi (ORCID: https://orcid.org/0000-0002-0622-1395)
- Shengquan Zhang (ORCID: https://orcid.org/0000-0001-6098-1208)
- Jie Li (ORCID: https://orcid.org/0000-0003-2343-1658)
- Yinshun Zhang (ORCID: https://orcid.org/0000-0001-6810-2781)
- Fujun Liu (ORCID: https://orcid.org/0000-0001-6708-207X)
- Lin Yuan (ORCID: https://orcid.org/0000-0003-2065-2666)
- Hui Tao (ORCID: https://orcid.org/0000-0002-3114-5638)
- Shuhai Zhang
- Ruoyu Yang (ORCID: https://orcid.org/0000-0002-7066-457X)
- Sumei Zhang
Institutions
- Anhui Medical University (CN)
- Chinese PLA General Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Materials Today Bio
- Published
- 2025-05-22
- DOI
- https://doi.org/10.1016/j.mtbio.2025.101872
- Citations
- 7
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 10.30