Avidity of pertussis toxin antibodies following vaccination with genetically versus chemically detoxified pertussis toxin-containing vaccines during pregnancy
Compared with chemically detoxified vaccines, vaccination during pregnancy with recombinant genetically detoxified acellular pertussis vaccine at lower PT concentration provides infants with at least similar or higher quality PT-IgG antibodies. Consequently, recombinant pertussis vaccines may offer comparable or better protection against pertussis.
Authors
- Giuseppe Del Giudice (ORCID: https://orcid.org/0000-0002-4585-4590)
- Bahaa Abu-Raya (ORCID: https://orcid.org/0000-0002-3528-0343)
- Anita H.J. van den Biggelaar (ORCID: https://orcid.org/0000-0002-3323-7261)
- Yuxiao Tang (ORCID: https://orcid.org/0000-0001-7576-8928)
- Wassana Wijagkanalan (ORCID: https://orcid.org/0000-0003-1363-3547)
- Hong Thai Pham
- Niranjan Bhat (ORCID: https://orcid.org/0000-0001-9249-5028)
Institutions
- Dalhousie University (CA)
- Program for Appropriate Technology in Health (US)
- Izaak Walton Killam Health Centre (CA)
- Nova Scotia Health Authority (CA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1569151
- Citations
- 1
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- Bill and Melinda Gates Foundation
- Chulalongkorn University
- Mahidol University
- Faculty of Medicine Siriraj Hospital, Mahidol University