A Dual Role of HGF-ERK Signaling in IL6/HGF-induced Hepatocyte Proliferation
We report a dual role of HGF-ERK signaling in hepatocyte culture. By blocking the growth-inhibiting TGFβ pathway, we could further promote H6-induced hepatocyte proliferation.
Authors
- Bing Li (ORCID: https://orcid.org/0000-0001-9502-7844)
- Jiani Yu (ORCID: https://orcid.org/0000-0002-7518-6220)
- Xin Xie (ORCID: https://orcid.org/0000-0003-2314-4800)
- Na Suo
- Shun Wang (ORCID: https://orcid.org/0000-0003-4795-2087)
- Jingwei Zhang (ORCID: https://orcid.org/0000-0002-0855-7327)
- Shitong Wang (ORCID: https://orcid.org/0000-0003-4341-3510)
- Ren Guo
Institutions
- Shanghai Institute of Materia Medica (CN)
- National Center for Drug Screening (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101538
- Citations
- 7
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 9.25