PROFIL FITOKIMIA DAN BIOAKTIVITAS EKSTRAK DAUN SAWO: SEBUAH ULASAN ILMIAH

<p><em>The utilization of traditional medicinal plants in Indonesia is an integral part of community medicine practices. <span style="text-decoration: underline;">Manilkara kauki</span> and <span style="text-decoration: underline;">Manilkara zapota</span> leaves are medicinal plants that attract attention due to their bioactive compound content and have been used traditionally for a long time. However, scientific reviews of the phytochemical profile and bioactivity of sapodilla leaf extracts, both Manilkara kauki and Manilkara zapota, are still limited. This review aims to discuss in-depth and comprehensively sapodilla leaf extracts, both Manilkara kauki and Manilkara zapota, especially phytochemical profiles and their bioactivity. This scientific review uses a literature study approach with data from 2012-2024 obtained from open-access platforms, especially Google Scholar. The study results showed that the phytochemical compounds found in the extracts of <span style="text-decoration: underline;">Manilkara kauki</span> leaves included flavonoids, glycosides, tannins, saponins, steroids/terpenoids, and alkaloids. In contrast, the phytochemicals found in the extracts of <span style="text-decoration: underline;">Manilkara zapota</span> were flavonoids, tannins, saponins, steroids, terpenoids, and alkaloids. <span style="text-decoration: underline;">Manilkara kauki</span> leaf extract has many bioactivities including anti-bacterial, anti-diabetic, anti-fungal, antioxidant, and anti-tyrosinase. Meanwhile, <span style="text-decoration: underline;">Manilkara zapota</span> leaf extract also showed antibacterial, antidiabetic, antioxidant, and anti-diarrhea activities. Further research is needed to optimize the therapeutic potential of these two plants.</em></p>