A clinical study to evaluate the efficacy of Mashadi Ghrita in Ksheena Shukra (oligospermia)

Background: Ksheena Shukra bears resemblance to Oligospermia, a condition where sperm count is below 15 million/ml. In Ksheena Shukra, both the quantity and quality of Shukra Dhatu are impaired, while Oligospermia specifically refers to a reduction in sperm count. Ksheena Shukra is classified as one of the eight types of Shukradushti in classical literature and is identified as a Vata-Pittaja Vyadhi. Aim: The aim of the study was to evaluate the efficacy of an Ayurvedic formulation named Mashadi Ghrita which was unexplored Aushadha Yoga explained in the text Vaidya Manorama’s Rasayana-Vajikaran Adhyaya for the management of Ksheena Shukra (Oligospermia) Materials and Methods: 30 patients fulfilling the diagnostic and inclusion criteria were selected for an open labelled single arm study. They received the trial drug, Mashadi Ghrita in the dosage of 6ml BD before food with Ushnodaka (lukewarm water) as Anupana for the period of 60 days. The assessment was done on the baseline 0th day, 31st day, 61st day and 76th day. Results: After the clinical study, the trial group showed effective results in mitigating Ksheena Shukra. On statistical analysis within the group, it showed the significant effect on the objective parameters like Semen Volume, Semen pH, Sperm Count, Liquefaction Time. Conclusion: On statistical analysis within the group on different intervals, Mashadi Ghrita was beneficial in the management of Ksheena Shukra (Oligospermia). It showed improvement in the Lakshanas of Ksheena Shukra and seminal parameters.