A Comparative Clinical Trial on Harenvadi Churna Lepa versus Yashtimadhu Churna Lepa with Vilvadi Agada as common internal medicine in Kshalana Visha with special reference to Detergent dermatitis

Introduction: Detergents are used in almost every household in developed and developing countries. The resulting dermatitis occurs mainly on the hands, is caused by irritation from cleaning agents, and is highly stressful and debilitating. The main objective of the study was to evaluate the comparative effect of Harenvadi Curna Lepa with Yashtimadhu Curna Lepa in reducing Four cardinal features of Kshalana Visha, viz. Erythema, Dryness, Pruritus and Burning sensation. Harenvadi Curna Lepa mentioned in Aṣṭanga Samgraha Visha Pratiṣedha Adhyāya, contains 4 drugs, each having Vishahara property and specially indicated in Garopahatha Tvacha. Methods: The study was a comparative clinical trial involving 86 participants diagnosed with detergent dermatitis, randomly allocated in to trial and control groups. Trial group recieved Harenvadi Curna and the control group received Yashtimadhu Curna. Both groups received Vilwadi Agada as the common internal medicine. Assessment were done before treatment, 8th, 15th and 22nd day (follow-up). Result: Result concluded that trial drug was more efficacious than control drug in managing 4 cardinal symptoms of Kshalana Visha (p<0.001). Discussion: There is significantly superior difference in the efficacy of Harenvadi Curna Lepa when compared to Yashtimadhu Curna as Lepa in the management of Kshalana Visha w.s.r. to Detergent dermatitis.