Derivatives of sterically hindered phenols and pyridinecarboxylic acids as prospective radioprotectors
New compounds consisting of 2,6-di-<em>tert</em>-butylphenol and isomeric pyridinecarboxamide moieties as well as their water-soluble hydrochlorides were synthesized. The compounds appeared to be potent antioxidants and radioprotectors, with no significant difference in activity between the pyridine bases and their salts. The cytotoxicity assay showed no significant toxic impact from any of the substances, making them promising candidates for further investigation.
Authors
- Е. А. Никитин (ORCID: https://orcid.org/0000-0002-6775-7142)
- Alina A. Markova (ORCID: https://orcid.org/0000-0002-3867-8760)
- Konstantin Alexandrovich Lyssenko (ORCID: https://orcid.org/0000-0002-3500-1287)
- В. Н. Морозов (ORCID: https://orcid.org/0000-0003-4481-3954)
- V. A. Kuz’min (ORCID: https://orcid.org/0000-0001-6586-3251)
- E. F. Shevtsova (ORCID: https://orcid.org/0000-0003-2887-1185)
- Minh Tuan Nguyen (ORCID: https://orcid.org/0000-0002-4185-5844)
- Е. Р. Милаева (ORCID: https://orcid.org/0000-0002-5489-3866)
- М. А. Колыванова (ORCID: https://orcid.org/0000-0002-7810-8914)
- A. В. Белоусов (ORCID: https://orcid.org/0000-0001-9705-7692)
- Nikita S. Lifanovsky
- V. D. Tyurin (ORCID: https://orcid.org/0000-0003-1671-991X)
- Zahra A Ahmedova
Institutions
- Lomonosov Moscow State University (RU)
- Institute of Biochemical Physics NM Emanuel (RU)
- Institute of Physiologically Active Compounds (RU)
- Federal Medical-Biological Agency (RU)
Publication Details
- Journal
- Mendeleev Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.71267/mencom.7671
- Citations
- 1
- Primary Topic
- Free Radicals and Antioxidants
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Russian Science Foundation