A novel molecular platform for co-delivery of monomethyl auristatin E and ispinesib to prostate cancer cells
A conjugate for co-delivery of ispinesib and monomethyl auristatin E was prepared using methods of peptide synthesis and azide-alkyne cycloaddition. Cytotoxicity studies of the mentioned drug pair were performed. <em>In vitro</em> studies of the synthesized bimodal conjugate were conducted on prostate cancer cell lines.
Authors
- Dmitry A. Skvortsov (ORCID: https://orcid.org/0000-0001-8336-8596)
- Н. И. Волкова (ORCID: https://orcid.org/0000-0003-4874-7835)
- Anastasia A. Uspenskaya (ORCID: https://orcid.org/0000-0002-2451-8336)
- Nikolay Y. Zyk (ORCID: https://orcid.org/0000-0002-5302-9160)
- Elena Kimovna Beloglazkina (ORCID: https://orcid.org/0000-0001-6796-8241)
- Alexander G. Majouga (ORCID: https://orcid.org/0000-0002-5184-5551)
- Aleksei E. Machulkin (ORCID: https://orcid.org/0000-0001-7975-0346)
- Nikolai Vasil'evich Zyk (ORCID: https://orcid.org/0000-0002-3771-116X)
- Anastasiia Yuryevna Kolchanova
Institutions
- Peoples' Friendship University of Russia (RU)
- D. Mendeleyev University of Chemical Technology of Russia (RU)
- Lomonosov Moscow State University (RU)
Publication Details
- Journal
- Mendeleev Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.71267/mencom.7661
- Citations
- 2
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Russian Science Foundation