Trithiacrown ethers incorporating tetrahydropyridine subunit: synthesis, <em>in vitro</em> and <em>in silico</em> studies of inhibitory activity against α-glucosidase
Several novel thiacrown ether derivatives incorpotating tetrahydropyridine subunits have been prepared by the three-component domino reaction of dialdehyde podand, alkyl acetoacetates and ammonium acetate as the nitrogen source. The inhibitory activity of the compounds obtained against α-glucosidase was tested, which revealed two excellent antidiabetic compounds with low IC<sub>50</sub> values in comparison with control drug. Docking studies proposed the plausible interaction between the synthesized compounds and α-glucosidase receptor.
Authors
- Van Tran (ORCID: https://orcid.org/0000-0001-7878-1327)
- Nhung T. Dao (ORCID: https://orcid.org/0000-0002-0691-7106)
- Lê Tuấn Anh (ORCID: https://orcid.org/0000-0001-9169-7453)
- Dat T. Nguyen (ORCID: https://orcid.org/0000-0003-2750-3145)
- Trinh Van Le (ORCID: https://orcid.org/0000-0002-6763-7044)
- Linh M. Nguyen (ORCID: https://orcid.org/0000-0003-4280-0279)
Institutions
- Vietnam National University, Hanoi (VN)
- Thai Nguyen University (VN)
- Thai Nguyen University of Medicine and Pharmacy
Publication Details
- Journal
- Mendeleev Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.71267/mencom.7679
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00