Synthesis of daidzein derivatives for targeted drug delivery
A new protocol was developed for the synthesis of daidzein derivatives bearing 7-positioned linkers with carboxy and amino functions. The key step of the scheme is the Suzuki cross-coupling, the optimized procedures provide high yields and do not require chromatographic purification. This approach is advantageous for further linker elongation necessary for anchoring and drug-coupling; the compounds obtained are regarded as tumor-directing carriers.
Authors
- Pavel N. Solyev (ORCID: https://orcid.org/0000-0002-5546-4975)
- Elena A. Morozova (ORCID: https://orcid.org/0000-0003-2922-2793)
- Vitalia V. Kulikova (ORCID: https://orcid.org/0000-0003-0618-1407)
- Svetlana V. Revtovich (ORCID: https://orcid.org/0000-0003-1594-9334)
- V. S. Koval (ORCID: https://orcid.org/0000-0002-1181-104X)
- A. Sidorova
- Natalya V. Anufrieva (ORCID: https://orcid.org/0000-0002-6611-8840)
- A. A. Stomakhin
Institutions
- Engelhardt Institute of Molecular Biology (RU)
Publication Details
- Journal
- Mendeleev Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.71267/mencom.7722
- Primary Topic
- Phytoestrogen effects and research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation