Monoterpene amino alcohols in multicomponent synthesis of chiral hetero- and carbocycles
The reaction between ethyl trifluoroacetoacetate, acetone and 4-amino-3-hydroxycarane having tertiary hydroxy group affords the 5-hydroxy-5-(trifluoromethyl)cyclohex-2-en-1-one derivative bearing 3-positioned (3-hydroxycaran-4-yl)amino moiety. The analogous reaction with 3-amino-2-hydroxyapopinane having functional groups at the secondary carbon atoms gives the product of further heterocyclization with perhydro 6,8-methanobenz[4,5]oxazolo[3,2-<em>a</em>]pyridine framework.
Authors
- Д. В. Судариков (ORCID: https://orcid.org/0000-0001-5640-6956)
- Л. Л. Фролова
- Марина А. Ежикова (ORCID: https://orcid.org/0000-0001-5689-5569)
- Павел А. Слепухин (ORCID: https://orcid.org/0000-0001-8132-9905)
- Mikhail Isaakovich Kodess
- А. А. Тумашов (ORCID: https://orcid.org/0000-0001-9383-2006)
- S.O. Kushch
- В. И. Салоутин (ORCID: https://orcid.org/0000-0003-1976-7861)
- Marina V. Goryaeva (ORCID: https://orcid.org/0000-0002-7853-688X)
- Yu.V. Burgart
Institutions
- Institute of Organic Synthesis (RU)
- Ural Branch of the Russian Academy of Sciences (RU)
- Institute of Chemistry, Komi Science Center (RU)
Publication Details
- Journal
- Mendeleev Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.71267/mencom.7699
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education and Science of the Russian Federation
- Russian Science Foundation