One Case of Stillbirth Caused by Maternal Fetal Transfusion Syndrome and Literature Review

Fetomaternal hemorrhage (FMH) is an obstetric emergency characterized by the pathological transfer of fetal erythrocytes across the placental barrier into the maternal circulation. FMH can lead to severe complications, including fetal anemia, non-immune hydrops, and perinatal mortality. The pathogenesis involves multifactorial interactions, such as placental barrier dysfunction, hemodynamic abnormalities, and vascular endothelial injury. Due to its insidious clinical presentation and limitations in current diagnostic modalities, FMH is prone to missed or delayed diagnosis. This study presents a case of intrauterine fetal demise secondary to FMH and conducts a narrative literature review to establish an early warning indicator system, refine risk assessment models, and propose evidence-based individualized intervention strategies. The objectives are to enhance clinical recognition, standardize diagnostic and therapeutic protocols, and ultimately improve perinatal outcomes.

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Publication Details

Journal
Journal of Biosciences and Medicines
Published
2025-01-01
DOI
https://doi.org/10.4236/jbm.2025.135012
Primary Topic
Hemoglobinopathies and Related Disorders
Type
article
Field-Weighted Citation Impact
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article

One Case of Stillbirth Caused by Maternal Fetal Transfusion Syndrome and Literature Review

Hong Ma, Fangxin Li, Yuntao Cen, Xian Chen et al.
Journal of Biosciences and Medicines
Hemoglobinopathies and Related Disorders
article

One Case of Stillbirth Caused by Maternal Fetal Transfusion Syndrome and Literature Review

Hong Ma, Fangxin Li, Yuntao Cen, Xian Chen, Qiuping Wang
article en

Abstract

Fetomaternal hemorrhage (FMH) is an obstetric emergency characterized by the pathological transfer of fetal erythrocytes across the placental barrier into the maternal circulation. FMH can lead to severe complications, including fetal anemia, non-immune hydrops, and perinatal mortality. The pathogenesis involves multifactorial interactions, such as placental barrier dysfunction, hemodynamic abnormalities, and vascular endothelial injury. Due to its insidious clinical presentation and limitations in current diagnostic modalities, FMH is prone to missed or delayed diagnosis. This study presents a case of intrauterine fetal demise secondary to FMH and conducts a narrative literature review to establish an early warning indicator system, refine risk assessment models, and propose evidence-based individualized intervention strategies. The objectives are to enhance clinical recognition, standardize diagnostic and therapeutic protocols, and ultimately improve perinatal outcomes.

Journal of Biosciences and MedicinesVol. 13(05)
Gender equality
Openalex Percentile: Top 84%
Hemoglobinopathies and Related Disorders
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