Recent Advances in Electrochemical Benzylic C(sp<sup>3</sup>)−H Functionalization
Direct benzylic C(sp 3 )H functionalization has emerged as a topic in organic synthesis due to its critical role in constructing complex and valuable molecules. Among the various methodologies employed, electroorganic synthesis has garnered considerable attention in diversifying benzylic C(sp 3 )H functionalization. In recent years, substantial progress has been made in electrochemical benzylic C(sp 3 )H functionalization. However, a comprehensive review summarizing recent advancements in this area is still lacking. This review provides an overview of the latest developments (2021–2025) in electrochemical benzylic C(sp 3 )H functionalization, with a particular emphasis on mechanistic insights and practical applications in the synthesis of biologically active molecules. Additionally, current challenges and future perspectives in this field are discussed.
Authors
- Qiang Huang (ORCID: https://orcid.org/0000-0002-4363-6805)
- Anni Li (ORCID: https://orcid.org/0000-0002-5197-4329)
- Hongji Li (ORCID: https://orcid.org/0000-0002-6829-0257)
- Zhengjun He
Institutions
- Huaibei Normal University (CN)
- Zhengzhou University (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1002/ejoc.202500275
- Citations
- 5
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- Natural Science Foundation for Distinguished Young Scholars of Anhui Province
- National Natural Science Foundation of China
- Ministry of Education of the People's Republic of China