Development and optimization of human deuterium MR spectroscopic imaging at 3 T in the abdomen
We have shown the feasibility of abdominal deuterium MR spectroscopic imaging at 3 T using a flexible surface coil. Water measurements were obtained in healthy volunteers, and images were acquired in a patient with a renal tumor after drinking <sup>2</sup>H<sub>2</sub>O. The limited depth penetration of the surface coil may have advantages in characterizing early uptake of orally administered agents in abdominal organs, despite the high concentrations in the stomach which can pose challenges with other coil combinations.
Authors
- Elizabeth Latimer
- Rolf F. Schulte (ORCID: https://orcid.org/0000-0002-1334-1264)
- Mary A. McLean (ORCID: https://orcid.org/0000-0002-3752-0179)
- James Andrew Armitage (ORCID: https://orcid.org/0000-0002-3762-0911)
- Pascal Wodtke
- Ines Horvat‐Menih (ORCID: https://orcid.org/0000-0002-1373-6944)
- Ferdia A. Gallagher (ORCID: https://orcid.org/0000-0003-4784-5230)
- Alixander S. Khan (ORCID: https://orcid.org/0000-0002-9048-9553)
- Marta Wylot
- Jonathan R. Birchall (ORCID: https://orcid.org/0000-0003-3920-4038)
- Joshua Kaggie (ORCID: https://orcid.org/0000-0001-6706-3442)
- Huanjun Wang (ORCID: https://orcid.org/0000-0001-9089-7736)
- Grant Duncan Stewart (ORCID: https://orcid.org/0000-0003-3188-9140)
- Thomas J. Mitchell (ORCID: https://orcid.org/0000-0003-0761-9503)
- Ashley Grimmer (ORCID: https://orcid.org/0000-0001-6013-5271)
- Maria Jesus Zamora Morales
Institutions
- University of Cambridge (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Cancer Research UK Cambridge Center (GB)
- Siemens Healthineers (Germany) (DE)
- Addenbrooke's Hospital (GB)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1002/mrm.30556
- Citations
- 6
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.54
Funders
- Cancer Research UK
- Gates Cambridge Trust
- NIHR Cambridge Biomedical Research Centre