Temporary Erythropoiesis Hypoactivity Following Hypoxia‐Inducible‐Factor‐Prolyl‐Hydroxylase‐Inhibitor Discontinuation

Recently, hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have been introduced as a therapeutic option for anemia, a common complication of chronic kidney disease. Although HIF-PHIs demonstrate efficacy in managing anemia, their administration may lead to dependence on upregulated hypoxia-inducible factors. Here, we report two maintenance hemodialysis cases that experienced temporary erythropoiesis hypoactivity following HIF-PHI discontinuation.

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Publication Details

Journal
Hemodialysis International
Published
2025-05-20
DOI
https://doi.org/10.1111/hdi.13258
Primary Topic
Erythropoietin and Anemia Treatment
Type
article
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article

Temporary Erythropoiesis Hypoactivity Following Hypoxia‐Inducible‐Factor‐Prolyl‐Hydroxylase‐Inhibitor Discontinuation

Masayuki Tanemoto
Hemodialysis International
Erythropoietin and Anemia Treatment
article

Temporary Erythropoiesis Hypoactivity Following Hypoxia‐Inducible‐Factor‐Prolyl‐Hydroxylase‐Inhibitor Discontinuation

Masayuki Tanemoto
article en

Abstract

Recently, hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have been introduced as a therapeutic option for anemia, a common complication of chronic kidney disease. Although HIF-PHIs demonstrate efficacy in managing anemia, their administration may lead to dependence on upregulated hypoxia-inducible factors. Here, we report two maintenance hemodialysis cases that experienced temporary erythropoiesis hypoactivity following HIF-PHI discontinuation.

Hemodialysis InternationalVol. 29(4)
Tokatsu Hospital (JP)
Good health and well-being
Openalex Percentile: Top 86%
Erythropoietin and Anemia Treatment
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