Naringin Alleviates Digoxin-induced Nephrotoxicity via Regulating Nrf2/HO-1 and PI3K/ AKT/TGF-β Cascades in Rats' Renal Tissues
The co-administration of naringin and digoxin can mitigate digoxin-mediated nephrotoxicity by introducing antioxidant action. This is done by maintaining effects on renal oxidative/antioxidant cycle and lethality via regulating AKT/ PI3k/ Smad3/ Smad7 signaling pathways.
Authors
- Al Shaimaa Ibrahim Rabie (ORCID: https://orcid.org/0000-0002-2229-9969)
- Mohamed S. Mady (ORCID: https://orcid.org/0000-0002-8754-0442)
- Amira S. A. Said (ORCID: https://orcid.org/0000-0002-6421-5970)
- Rasha H. Hussein
- Asmaa M. El-Kalaawy
- Hamed A. Said
- Mohammad M. AlAhmad (ORCID: https://orcid.org/0000-0003-0344-4056)
- Amr E. Ahmed (ORCID: https://orcid.org/0000-0003-0628-4422)
- Khalid S. Hashem (ORCID: https://orcid.org/0000-0001-5303-4739)
Institutions
- Beni-Suef University (EG)
- Cairo University (EG)
- Al Ain University (AE)
- Egyptian Atomic Energy Authority (EG)
- Fayoum University (EG)
Publication Details
- Journal
- Current Pharmaceutical Biotechnology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.2174/0113892010340746250421065424
- Citations
- 1
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 1.43