Role of Follicle-Stimulating Hormone Receptor Gene rs6165 C/T Polymorphism in Pathogenesis of Asthenozoospermia in Iranian Population

Background: Approximately half of all cases of infertility are caused by factors related to men, one of the most significant issues in human reproduction. The cause of male infertility is mainly unknown; however, it is demonstrated that genetic factors and single nucleotide polymorphisms (SNPs) are associated with male infertility. This study evaluated the association between follicle-stimulating hormone receptor (FSHR) gene polymorphism (rs6165 C/T) and idiopathic asthenozoospermia (AZS) in Iranian Azeri men. Methods: This study included 50 men with idiopathic sterility (case group) and 50 healthy men with normal fertility (control group) from East Azerbaijan, Iran. The genomic DNA was extracted, and the genotype was determined using Tetra-ARMS PCR. The collected data were analyzed using SPSS version 19.0. Results: The frequencies of CC, CT, and TT genotypes were 8%, 70%, and 22% in infertile patients, as compared with 2%, 92%, and 6% in healthy individuals. We found no significant difference between the case and control groups in terms of genotype and allele distribution. Conclusion: Our analysis found no significant correlation between FSHR gene rs6165 polymorphism and idiopathic AZS in Iranian Azeri males. However, more comprehensive studies with greater sample sizes are required from various geographic regions, races, and ethnic groups.