Retrospective Analysis of 226 Cases of Adverse Reactions to Antipsychotic Drugs in the Elderly Population

目的：分析老年人群抗精神病药物药品不良反应(adverse drug reactions, ADR)的发生特点，为老年人群用药安全提供参考。方法：从ADR监测系统提取2019年至2023年抗精神病药物所有ADR，筛选年龄 ≥ 60岁的ADR报告进行回顾分析。结果：共226例ADR纳入本次分析，ADR涉及神经、消化、心血管等多个系统/器官，主要表现为锥体外系反应、肝功能异常、心律失常等。结论：抗精神病药物ADR涉及多个系统/器官，给临床治疗带来不利影响。小剂量开始给药、注意给药疗程，注重ADR监测有利于提高老年人群用药安全。Objective: To provid reference for safe medication in the elderly population by analyze the characteristics and patterns of adverse drug reactions (ADR) associated with antipsychotic drugs. Methods: Extract all ADRs reported from 2019 to 2023 from the ADR monitoring system, screen for adverse drug reaction reports of drugs aged ≥ 60 years old with suspected use of antipsychotic drugs for retrospective analysis. Results: A total of 226 cases of ADR were included in this analysis, ADR involves multiple systems/organs such as the nervous system, digestive system, cardiovascular system, and endocrine system, mainly manifested as extra pyramidal reactions, abnormal liver function, arrhythmia, and abnormal glucose and lipid metabolism. Conclusion: Antipsychotic drug ADR involves multiple systems/organs, with complex and diverse clinical manifestations that may affect treatment outcomes. Starting small doses of medication, paying attention to the course of treatment, and monitoring ADR are beneficial for improving medication safety in the elderly population.