DETECTION OF JAK2 V617F MUTATION IN A PATIENT WITH C-KIT POSITIVE GASTROINTESTINAL STROMAL TUMOR: CASE REPORT
C-Kit is receptor tyrosine kinase which is involved in various signaling pathways and has been recognized in pathogenesis of several types of cancers including gastrointestinal stromal tumor (GIST). More than 50 years, scientist have been studied GIST and made advances in treatment based on c-Kit inhibition. One of the signaling pathway involving activation via c-Kit is the JAK/STAT pathway located on hematopoietic cells resulting activation of transcription of a variety of genes. Here, we provide a case report of patient with two malignancy c-Kit positive GIST and Essential Thrombocytemia (ET) positive for JAK2 V617F mutation.
Authors
- Simona Stojanovska Jakimovska
- Fana Lichoska Josifovikj
- Bozidar Kocoski
- Marija Popova Labacevska
- Lazar Cadievski
- Сања Трајкова (ORCID: https://orcid.org/0000-0002-2877-2729)
- Aleksandra Pivkova-Veljanovska (ORCID: https://orcid.org/0000-0002-4096-4686)
- Nevenka Ridova (ORCID: https://orcid.org/0000-0002-0230-8266)
- Milce Cvetanovski
- Svetlana Krstevska Balkanov
- Irina Panovska Stavridis
- Merve Purde
- Andrea Paunovska
- Martin Stojanovski
Institutions
- Ss. Cyril and Methodius University in Skopje (MK)
Publication Details
- Journal
- Journal of Morphological Sciences
- Published
- 2025-05-02
- DOI
- https://doi.org/10.55302/jms2581193t
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00