Enantioselective synthesis of spiro[indoline-3,1′-pyrazolo[1,2-<i>b</i>]phthalazine] derivatives <i>via</i> an organocatalytic three-component cascade reaction
An asymmetric synthesis of spiro[indoline-3,1'-pyrazolo[1,2-<i>b</i>]phthalazine] derivatives was first developed through an organocatalysed cascade Knoevenagel/Michael/cyclization reaction using a quinidine-derived squaramide. Under the optimized conditions, the three-component reaction of isatins, malononitrile (cyanoacetate) and phthalhydrazide yields the desired pyrazolophthalazinyl spirooxindoles in good yields (73-90%) with up to >99% enantiomer excess (ee).
Authors
- Luying Song (ORCID: https://orcid.org/0009-0008-3954-6285)
- Ying Jin (ORCID: https://orcid.org/0000-0003-1518-1601)
- Liming Wang (ORCID: https://orcid.org/0000-0002-6108-5453)
- Yuhong Sun (ORCID: https://orcid.org/0009-0004-6938-3422)
- Ren‐Bo An (ORCID: https://orcid.org/0000-0002-2564-0747)
Institutions
- Yanbian University (CN)
- Jilin Medical University (CN)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra01633a
- Citations
- 2
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- People's Government of Jilin Province
- Education Department of Jilin Province