Frequent Blood Donation Influences <em>DNMT3A</em>-Driven Clonal Hematopoiesis

Major Finding: Although frequent blood donors do not have higher incidence of preleukemic DNMT3A variants, there is an enrichment of DNMT3A mutants that promote EPO-responsive expansion.Concept: DNMT3A variants observed in frequent blood donors promote erythroid differentiation under persistent erythropoietic stress.Impact: This study sheds light on how diverse selection pressures alter the landscape of clonal hematopoiesis.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-044
Primary Topic
Acute Myeloid Leukemia Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Frequent Blood Donation Influences DNMT3A-Driven Clonal Hematopoiesis

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Cancer Discovery
Acute Myeloid Leukemia Research
article

Frequent Blood Donation Influences DNMT3A-Driven Clonal Hematopoiesis

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Abstract

Major Finding: Although frequent blood donors do not have higher incidence of preleukemic DNMT3A variants, there is an enrichment of DNMT3A mutants that promote EPO-responsive expansion.Concept: DNMT3A variants observed in frequent blood donors promote erythroid differentiation under persistent erythropoietic stress.Impact: This study sheds light on how diverse selection pressures alter the landscape of clonal hematopoiesis.

Cancer Discovery
Openalex Percentile: Top 86%
Acute Myeloid Leukemia Research
DOISourceOpenAlex
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Frequent Blood Donation Influences <em>DNMT3A</em>-Driven Clonal Hematopoiesis · Cancer Discovery (2025) | TGRS Research Map | TGRS