Resveratrol Alleviates Cognitive Impairment in Chronic Cerebral Hypoperfusion by Targeting Lingo-1, NgR1, p75, and RhoA/ROCK-2 Pathways
Resveratrol alleviates CCH-induced cognitive impairment by downregulating the Lingo-1/NgR1/p75 signaling axis and inhibiting RhoA-ROCK2 pathways. These findings highlight RES's potential as a therapeutic agent for vascular cognitive impairment associated with chronic hypoperfusion.
Authors
- Fatemeh Safari (ORCID: https://orcid.org/0000-0003-3943-8803)
- Mohabbat Jamhiri
- Fatemeh Zare Mehrjerdi (ORCID: https://orcid.org/0000-0002-5702-2038)
- Mansoureh Eslami
- Jalil Alizadeh Ghalenoei
Institutions
- Shahid Sadoughi University of Medical Sciences and Health Services (IR)
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Iranian journal of pharmaceutical research
- Published
- 2025-05-20
- DOI
- https://doi.org/10.5812/ijpr-158864
- Citations
- 1
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.84