O negative blood for everyone? No, transfusion and obstetrical management of a pregnant woman with an anti-public H1I1 antibody

A woman pregnant with her first child, blood group B+, showed pan-agglutination on antibody identification panels during her pregnancy follow-up. The absence of agglutination between the patient's plasma and a panel of B-phenotype red blood cells led to the conclusion of the presence of an anti-H1I1. This antibody is not thought to be responsible for fetal anemia or neonatal hemolytic disease, thus follow-up of fetal anemia is not necessary. However, in the event of transfusion, prior compatibility with blood of the same ABO group is necessary. In emergencies, group O depot blood should not be used whenever possible.

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Publication Details

Journal
Annales de biologie clinique
Published
2025-04-01
DOI
https://doi.org/10.1684/abc.2025.1962
Primary Topic
Blood groups and transfusion
Type
article
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article

O negative blood for everyone? No, transfusion and obstetrical management of a pregnant woman with an anti-public H1I1 antibody

Marta M. Gilson, Anaïs Devey
Annales de biologie clinique
Blood groups and transfusion
article

O negative blood for everyone? No, transfusion and obstetrical management of a pregnant woman with an anti-public H1I1 antibody

Marta M. Gilson, Anaïs Devey
article en

Abstract

A woman pregnant with her first child, blood group B+, showed pan-agglutination on antibody identification panels during her pregnancy follow-up. The absence of agglutination between the patient's plasma and a panel of B-phenotype red blood cells led to the conclusion of the presence of an anti-H1I1. This antibody is not thought to be responsible for fetal anemia or neonatal hemolytic disease, thus follow-up of fetal anemia is not necessary. However, in the event of transfusion, prior compatibility with blood of the same ABO group is necessary. In emergencies, group O depot blood should not be used whenever possible.

Annales de biologie cliniqueVol. 83(2)
Gender equality
Openalex Percentile: Top 86%
Blood groups and transfusion
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