STUDY OF ANTISTAPHYLOCOCCAL POTENTIAL OF NEWLY SYNTHESIZED ARYL ACYCLIC AMINO ALCOHOL DERIVATIVES

Background. Staphylococci remain priority pathogens among infectious agents. The growing antibiotic resistance of this species poses a serious threat to modern medicine. The limited number of effective antibiotics makes it difficult to treat staphylococcal infections and exacerbates their negative consequences for patients. Particular attention should be paid to Staphylococcus aureus’s resistance to methicillin, a “typical” phenomenon among hospital infections. Therefore, searching for new approaches to combat this pathogen is extremely important. Methods. The object of the study was 10 compounds of aryl acyclic amino alcohol derivatives and 50 strains of Staphylococcus aureus. The antistaphylococcal properties were determined by the disk diffusion method and the serial dilution. MRSA was identified by the phenotypic method using cefoxitin disks. The effectiveness of the compounds was determined by comparing the susceptibility of MRSA and MSSA. Results. Among the 50 strains, 24 were identified as containing the mecA gene by phenotypic features. The results of antibiotic susceptibility testing demonstrated predominant resistance to benzylpenicillin drugs. Following breakpoints of antibiotic resistance, resistance to benzylpenicillin was 74%. Sensitivity to tetracycline was found in 54% of strains, and to vancomycin - in 84%. The studied substances showed high efficiency against staphylococci. The activity of compounds Kc1, Kp18, Kp19 was on par with vancomycin, and the MIC for most isolates did not exceed 1 μg/ml. The inhibitory effect of the compounds was observed in the concentration range of 0.98-1.95 μg/ml. MSSA strains showed a slightly higher sensitivity, which may indicate the potential specificity of the compounds to PBP. Conclusions. The antimicrobial properties of aryl acyclic amino alcohol derivatives as potential antistaphylococcal agents were investigated. The effectiveness of the drugs in comparison with commercial drugs and between the groups of MSSA and MRSA was determined. A group of compounds with the most pronounced activity against S. aureus isolates, including MRSA, was identified.