Examining the Relation between Virus Mutation and Vaccination. A Data Analysis.
Public-domain available data documents the dynamics of variance characteristic of the COVID-19 pandemic. The enormous, but fractured, vaccination effort, and the still surprising dynamics of variants suggest possible inferences. The premise of the data analysis subject of this report is that vaccination, as an anticipatory action, is supposed to be preventive. The timeline of vaccine development for the large number of coronavirus forms suggests that the window of opportunity for prevention was missed. As a consequence, medicine was asked to react by finding means and methods for controlling the parameters of a pandemic. Various interventions were pursued under the pressure of the situation. As the record shows, such interventions can result in intentional or unintentional selective pressure on the virus associated with pandemic. The hypothesis that this pressure may favor the emergence of variants informs the research presented in this study. We examined mutations that result in partial immune evasion, not as an accident, but in connection to the vaccination effort. The data analysis performed suggests that the occurrence and frequency of vaccine-resistant mutations correlate with vaccination rates in certain regions.
Authors
- Ayush Sharma (ORCID: https://orcid.org/0000-0001-5038-1647)
- G. C. Shekar
- Mihai Nadin (ORCID: https://orcid.org/0000-0001-9712-8921)
Publication Details
- Journal
- Journal of Vaccinology JV
- Published
- 2025-04-14
- DOI
- https://doi.org/10.29245/2694-068x/2025/1.1101
- Primary Topic
- Vaccine Coverage and Hesitancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00