Effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition in chronic coronary disease: a subanalysis of the LoDoCo2 trial
Pericoronary inflammation did not differ among participants who received low-dose colchicine compared with placebo. Low-dose colchicine was associated with a higher volume of calcified plaque, particularly dense calcified plaque, which is considered a feature of plaque stability.
Authors
- Ruud A H M Aarts
- Kajetan Grodecki (ORCID: https://orcid.org/0000-0002-0358-5679)
- Jan Hein Cornel (ORCID: https://orcid.org/0000-0002-1006-2112)
- Aernoud T.L. Fiolet
- Remco J.J. Knol (ORCID: https://orcid.org/0000-0003-1089-2981)
- Arend Mosterd (ORCID: https://orcid.org/0000-0002-6906-2643)
- Damini Dey (ORCID: https://orcid.org/0000-0003-2236-6970)
- Tjerk S.J. Opstal (ORCID: https://orcid.org/0000-0003-3654-0327)
- Andrew Lin (ORCID: https://orcid.org/0000-0003-0348-7697)
- Jacek Kwieciński (ORCID: https://orcid.org/0000-0001-8202-6359)
- Stefan M. Nidorf
- Birgitta K. Velthuis (ORCID: https://orcid.org/0000-0002-2542-9474)
- Priscilla McElhinney (ORCID: https://orcid.org/0000-0002-7642-6804)
- Bas Kietselaer (ORCID: https://orcid.org/0000-0002-0096-8594)
- Jeroen Schaap
- Annemieke M F A Tutein Nolthenius
- Julie Tutein Nolthenius
Institutions
- Cedars-Sinai Medical Center (US)
- Mayo Clinic (US)
- Radboud University Nijmegen (NL)
- Sir Charles Gairdner Hospital (AU)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Noordwest Ziekenhuisgroep (NL)
- Northwest Hospital (US)
- Werkgroep Cardiologische centra Nederland (NL)
- Amphia Ziekenhuis (NL)
- Monash Health (AU)
- Zuyderland Medisch Centrum (NL)
- Institute of Cardiology (PL)
- Australian Centre for Heart Health (AU)
- Amsterdam University Medical Centers (NL)
- Meander Medisch Centrum (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Heart
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1136/heartjnl-2024-325527
- Citations
- 5
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 6.94
Funders
- National Heart Foundation of Australia
- ZonMw