Hepatic Glucose Uptake During Euglycemic Hyperinsulinemia Associates With Glycemia During Oral Glucose Tolerance Test
Hepatic GU measured during hyperinsulinemic euglycemic clamp is an independent predictor of OGTT glucose area under the curves even when accounting for well-known other factors affecting glycemic control. This finding supports the idea that insulin-mediated hepatic GU, and more broadly, first-pass glucose extraction, have a meaningful contribution to glycemic control. Thus, this measurement provides useful information about hepatic insulin sensitivity in the more physiologic conditions of the OGTT which may be useful when studying the pathophysiology of impaired glucose tolerance and when evaluating potential treatments for impaired glycemic control.
Authors
- Jarna C. Hannukainen (ORCID: https://orcid.org/0000-0002-8692-4049)
- Heidi Immonen (ORCID: https://orcid.org/0000-0001-6510-3455)
- Miikka‐Juhani Honka (ORCID: https://orcid.org/0000-0001-9875-5863)
- Aino Latva‐Rasku (ORCID: https://orcid.org/0000-0001-8786-9160)
- Eleni Rebelos (ORCID: https://orcid.org/0000-0003-3050-8692)
- Pirjo Nuutila (ORCID: https://orcid.org/0000-0001-9597-338X)
- Laura Pekkarinen (ORCID: https://orcid.org/0000-0002-5596-0485)
- Nelli Tuomola
- Kari K. Kalliokoski (ORCID: https://orcid.org/0000-0002-8893-7126)
- Andrea Mari (ORCID: https://orcid.org/0000-0002-1436-5591)
- Leena Koukkari
Institutions
- University of Pisa (IT)
- University of Turku (FI)
- Turku University Hospital (FI)
- Turku PET Centre (FI)
- Neuroscience Institute (IT)
- Laiko General Hospital of Athens (GR)
- National Research Council (IT)
- Nara Institute of Science and Technology (JP)
Publication Details
- Journal
- Journal of the Endocrine Society
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1210/jendso/bvaf054
- Citations
- 4
- Primary Topic
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Type
- article
- Field-Weighted Citation Impact
- 5.18