The clinical effect of an implanted vagus nerve stimulator in a patient with chronic cluster headache and focal epilepsy – A case report

In this case, iVNS was followed by >75% decrease in CH attack frequency. While natural disease course or placebo effect cannot be excluded, (i) the continued effect 70 weeks post-surgery, (ii) the dose-response effect with stimulation settings, and (iii) return of daily attacks during temporary iVNS deactivation suggest that iVNS could be responsible for the decreased attack frequency. As patients with CCH need more treatment options, further research into VNS as preventive treatment for CCH could be beneficial.